Insulin receptor substrate 2 (IRS2)-deficiency delays liver fibrosis associated to cholestatic injury
نویسندگان
چکیده
منابع مشابه
Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
Endothelial cells are considered to be essential for normal pancreatic β-cell function. The current study attempted to demonstrate the role of insulin receptor substrate-2 (Irs2) in endothelial cells with regard to insulin secretion. Endothelial cell-specific Irs2 knockout (ETIrs2KO) mice exhibited impaired glucose-induced, arginine-induced, and glucagon-induced insulin secretion and showed glu...
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We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or JNK2 may promote apoptosis by inhibiting the activity of the pro-survival Akt pathway, the effect of JNK3 on Akt has not been documented. This...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2019
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.038810